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AM-1220 kaufen
Limited Stock
Preis pro Einheit (Gramm):
 € 16.10
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Preis
10 - 20
€ 16.10
50 - 80
€ 13.76
100 - 100
€ 10.55
250 - 250
€ 8.55
500 - 500
€ 7.03
1000 - 1000
€ 5.56
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AM-1220 is research chemical with moderate selective effect on cannabinoid receptors CB 1 and CB 2. This chemical is more selective to CB 1 receptors rather that to CB 2 receptors.

Its effect on CB 2 receptors is 19 times stronger. The duration of AM-1220 effect on human body may last up to one hour. AM-1220 begins affecting central nervous system very quickly after getting into the blood. Such quick effect of this research chemical can be explained by lack of metabolism reactions. AM-1220 is also known under its full chemical name which is (R)-(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone. The formula of this research chemical is C26H26N2O . (R)-(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone is a white crystalline powder. AM-1220 initially was discovered by Thomas D'Ambra from Sterling Winthrop. Later this research chemical was studied more thoroughly by a team led by Alexandros Makriyannis from the University of Connecticut. Generally AM-1220 is a research chemical that serves for laboratory and science research purposes.

AM-1220 is selective agonist for the cannabinoid receptor CB1, with around 19x selectivity for CB1 over the related CB2 receptor.It was originally invented in the early 1990s by a team led by Thomas D'Ambra at Sterling Winthrop, but has subsequently been researched by many others, most notably the team led by Alexandros Makriyannis at the University of Connecticut. The (piperidin-2-yl)methyl side chain of AM-1220 contains a stereocenter, so there are twoenantiomers with quite different potency, the (R) enantiomer having a Ki of 0.27nM at CB1while the (S) enantiomer has a much weaker Ki of 217nM.[3] A number of related compounds are known with similar potent cannabinoid activity, with modifications such as substitution of the indole ring at the 2- or 6- positions, the naphthoyl ring substituted at the 4- position or replaced by substituted benzoyl rings or other groups, or the 1-(N-methylpiperidin-2-ylmethyl) group replaced by similar heterocyclic groups such as N-methylpyrrolidin-2-ylmethyl or N-methylmorpholin-3-ylmethyl AM-1220 was first detected as an ingredient of synthetic cannabis smoking blends in 2010.

Systematic (IUPAC) name
(R)-(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone
Clinical data
Pregnancy cat. ?
Legal status banned under analog laws in some US states
Identifiers
CAS number 137642-54-7 Yes (racemic)
134959-64-1 ((R) enantiomer)
ATC code ?
PubChem CID 9929889
ChemSpider 26231035 Yes
Chemical data
Formula C26H26N2O
Mol. mass 382.497 g/mol




Kommentare
( 20 )
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